Table 1

Tumor and metastasis incidence after orthotopic CT-26 tumor cell injection

Mice received orthotopical injections of CT-26 colon adenocarcinoma cells, and treatment was initiated. Rapamycin was given i.p. at 1.5 mg/kg/day starting the second day, and 5-FU was given twice (days 3 and 10) at 100 mg/kg. Mice were sacrificed on day 14.

TreatmentOrthotopic tumorLymph node metastasisLiver metastasis
Control (saline)7/77/74/7
5-FUa8/83/81/8
Rapamycin7/80/80/8
5-FU + rapamycin1/80/80/8
  • a 5-FU, 5-fluorouracil.