Table 3

Mean (SD) pharmacokinetic parameter values of parent and total BMS-275291 at the recommended phase II dose of 1200 mg/day (13 patients)

AnalyteCmax ng/mlTmaxa hAUC (24h) ng · h/mlCminb ng/ml
Parent BMS-275291
 Day 110671 (4262)0.5 (0.5, 4.0)29553 (11140)
 Day 158192 (4439)1.0 (0.5, 2.0)24276 (10347)158 (65)
 Day 297412 (4582)1.0 (0.5, 4.0)24496 (12176)
Total BMS-275291
 Day 136983 (17099)1.0 (0.5, 4.0)172611 (75095)
 Day 1535862 (18428)1.0 (0.5, 4.0)330820 (142886)8112 (3114)
 Day 2934440 (17197)1.0 (0.5, 6.0)357451 (163266)
  • a Observed Tmax.

  • b Based on an average of values obtained on days 2, 8, 15, 16, 22, 29, and 30.