Table 3

Plasma methionine concentration (μm)a in monkeys during repeated rMETase treatment (n = 4)

Four monkeys were treated with 4000 units/kg rMETase for 14 days three times per day. Blood was sampled on the indicated days and measured for methionine by HPLC as described in “Materials and Methods.”

Time points (h)Day 1Day 5Day 9Day 14Day 66
011.3 ± 3.961.90 ± 1.122.17 ± 1.241.35 ± 1.0912.56 ± 0.75
100000
200000
400000
81.33 ± 0.601.68 ± 0.761.37 ± 0.610.92 ± 0.620.98 ± 0.21
  • a Limit of detection, <0.5 μm.