Table 4

Hematology and blood chemistry analysis in rMETase-treated monkeys (n = 4)

Monkeys were treated with rMETase at 4000 units/kg for 14 days three times a day. Blood was sampled at the times indicated with the listed analytes tested as described in “Materials and Methods.”

Laboratory testTime (days after administration of rMETase)
PreDay 5Day 9Day 14Day 26Day 86
WBC (×109/liter)13.0 ± 2.111.2 ± 5.66.3 ± 2.412.0 ± 4.017.3 ± 6.915.4 ± 1.1
RBC (×1012/liter)6.28 ± 0.476.66 ± 1.174.31 ± 1.285.24 ± 1.544.12 ± 0.175.40 ± 0.49
Hgb (g/liter)141 ± 18134 ± 18102 ± 24113 ± 3485 ± 14121 ± 8
HCT0.49 ± 0.040.54 ± 0.100.33 ± 0.100.45 ± 0.120.39 ± 0.020.43 ± 0.04
PLT (×109/liter)366 ± 131283 ± 50324 ± 111475 ± 262617 ± 316371 ± 76
MCH (pg)22.5 ± 2.120.3 ± 0.921.6 ± 1.221.6 ± 1.420.7 ± 2.622.6 ± 0.6
MCV (fl)78.8 ± 5.781.6 ± 4.377.7 ± 4.985.3 ± 1.194.9 ± 1.879.3 ± 0.4
MCHC (g/liter)286 ± 20249 ± 16271 ± 21260 ± 7217 ± 24284 ± 9
ALT (units/liter)19 ± 1023 ± 1113 ± 39 ± 412 ± 681 ± 45
GGT (units/liter)74 ± 1057 ± 2062 ± 1750 ± 1242 ± 1955 ± 18
AKP (units/liter)383 ± 261423 ± 309374 ± 118351 ± 95351 ± 188207 ± 157
TP (g/liter)73.6 ± 2.650.5 ± 23.458.1 ± 1.758.8 ± 0.868 ± 1.273.7 ± 1.6
ALB (g/liter)47.2 ± 4.839.0 ± 8.429.9 ± 1.127.3 ± 2.029.3 ± 4.843.9 ± 4.5
GLB (g/liter)26.4 ± 3.029.9 ± 1.028.2 ± 2.632.1 ± 1.438.7 ± 3.729.8 ± 2.8
A/G1.8 ± 0.71.1 ± 0.11.1 ± 0.10.8 ± 0.10.7 ± 0.21.4 ± 0.3
TBIL (μmol/liter)6.3 ± 0.49.3 ± 4.514.2 ± 7.75.7 ± 1.58.5 ± 1.58.7 ± 1.5
DBIL (μmol/liter)5.5 ± 0.53.8 ± 1.55.1 ± 2.93.8 ± 0.86.7 ± 1.15.9 ± 0.8
IBIL (μmol/liter)0.9 ± 0.35.5 ± 3.59.2 ± 4.91.9 ± 0.81.8 ± 1.12.8 ± 0.7
CHOL (mmol/liter)3.14 ± 0.882.79 ± 1.021.58 ± 0.682.04 ± 0.842.83 ± 0.203.13 ± 0.37
TG (mmol/liter)0.53 ± 0.050.66 ± 0.170.74 ± 0.080.67 ± 0.330.65 ± 0.220.43 ± 0.13
GLU (mmol/liter)3.37 ± 0.853.91 ± 2.303.25 ± 0.554.14 ± 1.063.28 ± 0.922.33 ± 0.34
BUN (mmol/liter)4.96 ± 0.9813.67 ± 5.6110.71 ± 0.478.70 ± 1.207.37 ± 1.487.16 ± 1.28
CR (μmol/liter)141.3 ± 21.3123.1 ± 22.895.4 ± 7.589.0 ± 11.083.3 ± 7.4106.9 ± 9.1
AST (units/liter)30 ± 152 ± 2928 ± 1039 ± 1046 ± 656 ± 1
CK (units/liter)136 ± 49305 ± 120177 ± 17567 ± 4089 ± 21138 ± 27
LDH (units/liter)454 ± 86786 ± 179445 ± 69643 ± 128596 ± 84520 ± 31
Ca2+ (mmol/liter)2.99 ± 0.412.09 ± 0.962.26 ± 0.342.31 ± 0.112.54 ± 0.422.45 ± 0.18
Na+ (mmol/liter)169.2 ± 8.6158.7 ± 5.0155.4 ± 7.5151.3 ± 5.1145.6 ± 1.0157.0 ± 9.9
K+ (mmol/liter)5.27 ± 1.094.57 ± 0.525.05 ± 0.755.39 ± 1.016.06 ± 1.344.25 ± 0.21
Cl (mmol/liter)123.7 ± 4.2114.9 ± 3.7112.5 ± 6.7109.5 ± 4.7106.7 ± 5.3118.5 ± 6.4
  • a HCT, hematocrit; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; MCHC, mean corpuscular hemoglobin concentration; ALT, alanine aminotransferase; GGT, γ-glutamyl transpeptidase; AKP, alkaline phosphatase; TP, total protein; ALB, albumin; GLB, globulin; A/G, albumin/globulin; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin; CHOL, cholesterol; TG, triglycerides; GLU, glucose; BUN, blood urea nitrogen; CR, creatinine; AST, aspartate aminotransferase; CK, creatine phosphokinase; LDH, lactate dehydrogenase; Hgb, hemoglobin; PLT, platelets.