Table 1

Plasma methionine concentration (μm) after single escalating doses of rMETase

Animals were dosed at time 0 with the single dose of rMETase listed below. See “Materials and Methods” for details.

Time points (h)1000 units/kg2000 units/kg4000 units/kg
Monkey 950111Monkey 960383Monkey 960427Monkey 962147Monkey 970475Monkey 970985
017.414.0812.6611.0815.4526.46
0.5000000
1.0000000
2.0000000
4.0000000
8.05.934.143.244.620.991.85
12.08.915.535.287.225.616.12
24.010.4013.278.978.0712.2724.73