Table 2

Pharmacokinetic parameters of rMETase in monkeys

Monkeys were treated with the single dose of rMETase listed below. Blood was drawn, analyzed for plasma enzyme activity, and evaluated for the parameters listed below as described in “Materials and Methods.”

MonkeyCoa (units/ml)Ke (liters/h)Vc × 103 (units/ml)T1/2 (h)AUC (units/ml/h)CLs (ml/h)
2000 units/kg dose
 96214732.510.280.032.49116.698.75
 96042748.670.320.042.15144.8113.81
4000 units/kg dose
 97098522.640.240.042.8492.6743.13
 97047561.830.280.062.49221.7618.4
  • a Co, initial drug concentration; Ke, elimination constant; Vc, apparent volume of distribution; T1/2, biological half-life; AUC, area under (concentration-time) curve; CLs, total body clearance.