Table 1

Detection rate and range of hypermethylated genes in plasma of NPCa and controls

41 NPC patients43 normal controlsStatistical analysis of incidence Fisher’s test
IncidenceMean (range) copy/mlbIncidenceMean (range) copy/mlb
CDH119 (46%)297 (25–1056)4 (9%)52 (28–97)P < 0.000
DAP-Kinase8 (20%)338 (53–833)0P = 0.002
p158 (20%)267 (26–1000)0P = 0.002
p1617 (42%)539 (43–2334)1 (2%)(60)P < 0.000
RASSF1A2 (5%)71 (53–89)0P = 0.235
MLH100
At least one gene positive29 (71%)4 (8%)P < 0.001
  • a NPC, nasopharyngeal carcinoma.

  • b Copy number in 1-ml plasma sample of those positive patients or controls.