Table 2

Associations of circulating DNA and clinicopathological parameters of NPCa patients

NoMean DNA concentration (ng/ml)Hypermethylation (%)
CDH1DAP-Kinasep15p16RASSF1A
SexMale3024.8414 (47)8 (27)6 (20)13 (43)1 (3)
Female1139.555 (46)0 (0)2 (18)4 (36)1 (3)
P 0.193b1.000c0.083c1.000c0.736c0.470c
StagingI538.422 (4)0 (0)1 (20)1 (20)0 (0)
II1242.526 (50)2 (17)2 (17)4 (33)1 (8)
III920.795 (56)3 (33)2 (22)5 (56)1 (11)
IV1519.406 (40)3 (20)3 (20)7 (47)0 (0)
P 0.196d0.874d0.499d0.991d0.536d0.554d
Lymph node statusPositive2726.8313 (48)7 (26)6 (22)12 (45)1 (4)
Negative1432.566 (43)1 (7)2 (14)5 (36)1 (7)
P 0.869c1.000c0.207c0.692c0.742c0.572c
  • a NPC, nasopharyngeal carcinoma.

  • b Wilcoxon’s rank-sum test.

  • c Fisher’s exact test.

  • d χ2 test.