Table 1

Pharmacokinetic parameters after administration of imatinib 15 mg/kg i.v. over 30 min to 3 nonhuman primates

AnimalClTBa (ml/min/kg)VDSS (liter/kg)Plasma t1/2 β (min)AUCPlasmam·min)AUCCSFm·min)CSF:Plasma
IV 1144.635018021420.08
IV 264.155440231160.03
IV 3169.16821614930.06
Mean±SD12±55.9±2.8529±1672480±1340117±250.05±0.02
  • a ClTB, total body clearance; VDSS, volume of distribution at steady state; t1/2 β, terminal half-life; AUCPlasma, area under the concentration versus time curve in plasma; AUCCSF, area under the concentration versus time curve in CSF; CSF:Plasma ratio of the AUCCSF to AUCPlasma.