Table 2

Pharmacokinetic parameters after p.o. administration of p.o. imatinib (30 mg/kg) to 3 nonhuman primates

AnimalClTBa (ml/min/kg)Plasma t1/2 β (min)AUCPlasmam·min)AUCCSFm·min)CSF:Plasma
PO 1382731356930.07
PO 2473501078500.05
PO 3451741139420.04
Mean±SD43±5266±881191±14662±270.05±0.02
  • a ClTB, total body clearance; VDSS, volume of distribution at steady state; t1/2 β, terminal half-life; AUCPlasma, area under the concentration versus time curve in plasma; AUCCSF, area under the concentration versus time curve in CSF; CSF:Plasma ratio of the AUCCSF to AUCPlasma.