Table 1

Features of BEAS-2B and all-trans-retinoic acid (RA)-resistant BEAS-2B-R1 human bronchial epithelial cell lines

RA response referred to induced growth suppression. Resistance frequency indicated the number of cells from which a single RA-resistant cell line was derived. As depicted, RA resistance was infrequently detected in BEAS-2B cells. Cyclin degradation refers to RA induced degradation of cyclin D1 and cyclin E proteins.

Cell lineRA responseResistance frequencyCyclin degradationG1 arrest
BEAS-2BSensitive≤5 × 106SensitivePresent
BEAS-2B-R1ResistantN.A.aResistantInhibited
  • a N.A., not applicable.