Table 2

Modulation of chemotherapy effectiveness of CPT-11 by RDP58 in tumor-bearing mice

CPT-11 (mg/kg/day)RDP58 (mg/kg/day)Chemotherapy effectiveness
Mortality (%)Tumor regression (%)Time to relapse (day)
66.7 (1X MTDa)00447.2 ± 1.1
133.3 (2X MTD)05084b15.4 ± 1.1b
133.3 (2X MTD)100c85b15.5 ± 1.3b
  • a MTD, maximum tolerated dose.

  • b P < 0.05 (ANOVA).

  • c P < 0.05 (survival analysis).