Table 3

Effect of RDP58 on 4T1 mammary fat pad tumor growth and metastasis in mice

CPT-11 (mg/kg/day)RDP58 (mg/kg/day)Chemotherapy effectiveness
Mortality (%)Primary tumor size (mm3)Incidence of pulmonary metastasis (%)Number of pulmonary nodules
000134 ± 1010015 (10–27)
0100132 ± 9.110014 (9–21)
66.7 (1X MTDa)0086 ± 6.5b1006 (3–9)b
133.3 (2X MTD)04258 ± 5.8b572 (0–5)b
133.3 (2X MTD)10055 ± 6.0b582 (0–6)b
  • a MTD, maximum tolerated dose.

  • b P < 0.05 (ANOVA).