Table 2

Pharmacokinetic parameters obtained from 7 patients (mean ± SD) from the model described in Fig. 1<$REFLINK>

ParameterDay 1Day 5
Body weight (kg)69.1 ± 34.769.1 ± 34.7
Volume of distribution for free etoposide or catechol (ml)14764 ± 652314550 ± 7056
Volume of distribution for protein bound etoposide or catechol (ml)10537 ± 60679414 ± 5366
Volume of distribution for free etoposide or catechol (% of body weight)21.8 ± 2.321.2 ± 1.1
Volume of distribution for protein bound etoposide or catechol (% of body weight)15.7 ± 1.113.5 ± 3.5
K(0,1) (/min)0.0615 ± 0.02830.0803 ± 0.0412a
K(2,1) (/min)1.22 ± 1.491.19 ± 1.23
K(1,2) (/min)0.0728 ± 0.07470.0877 ± 0.0849
K(3,1) (/min)0.00234 ± 0.001880.00744 ± 0.00710
K(4,3) (/min)1.22 ± 1.491.19 ± 1.23
K(3,4) (/min)0.0728 ± 0.07470.0877 ± 0.0849
K(0,3) (/min)0.153 ± 0.1110.265 ± 0.290
Conversion of etoposide to catechol (%)3.6 ± 3.014.4 ± 22.2
  • a Day 5 parameter was significantly different (P < 0.05) from corresponding day 1 parameter.