Table 3

Pharmacokinetic parameters (mean ± SD) for total and protein-free etoposide from 7 patients

ParameterTotal etoposide on day 1Total etoposide on day 5Free etoposide on day 1Free etoposide on day 5
Cmaxa (μg/ml)24.1 ± 6.724.5 ± 5.61.28 ± 0.770.78 ± 0.14b
tmax (min)60.1 ± 0.460.1 ± 0.460.7 ± 1.962.1 ± 5.7
t1/2α (min)65.3 ± 24.361.7 ± 14.930.7 ± 17.947.1 ± 33.9
t1/2β (min)267 ± 67271 ± 129256 ± 51220 ± 141
AUC6h (μg·min/ml)2788 ± 6482586 ± 458154 ± 36123 ± 25b
AUC24h (μg·min/ml)3966 ± 12683358 ± 968b207 ± 54156 ± 55b
Mean residence time (min)286 ± 78240 ± 80257 ± 78213 ± 78
  • a Cmax, maximum concentration; tmax, time of maximum concentration; t1/2α, distribution half-life; t1/2β, elimination half-life; AUC, area under the plasma concentration-time curve.

  • b Day 5 parameter was significantly different (P < 0.05) from corresponding day 1 parameter.