Table 4

Pharmacokinetic parameters (mean ± SD) for total and protein-free etoposide catechol from 7 patients

ParameterTotal catechol on day 1Total catechol on day 5Free catechol on day 1Free catechol on day 5
Cmaxa (μg/ml)0.114 ± 0.0280.262 ± 0.107b0.0120 ± 0.00910.0186 ± 0.0082
tmax (min)150 ± 52105 ± 39137 ± 67103 ± 29
t1/2α (min)41.4 ± 18.838.5 ± 13.530.7 ± 17.947.1 ± 33.9
t1/2β (min)257 ± 115194 ± 92256 ± 51220 ± 140b
AUC6h (μg·min/ml)28.7 ± 5.964.8 ± 29.3b1.71 ± 0.663.18 ± 1.36b
AUC24h (μg·min/ml)55.9 ± 16.1105.4 ± 49.1b3.04 ± 1.044.89 ± 2.23b
  • a Cmax, maximum concentration; tmax, time of maximum concentration; t1/2α, distribution half-life; t1/2β, elimination half-life; AUC, area under the plasma concentration-time curve.

  • b Day 5 parameter was significantly different (P < 0.05) from corresponding day 1 parameter.