Table 5

Interpatient differences in AUC24ha of etoposide

PatientsAUC (μg·min/ml) Total etoposide day 1AUC (μg·min/ml) Total etoposide day 5AUC ratio of day 5 to day 1AUC (μg·min/ml) Free etoposide day 1AUC (μg·min/ml) Free etoposide day 5AUC ratio of day 5 to day 1
1390135720.922161410.65
2287426920.941361130.83
3364425070.691481010.68
4451540570.902601560.60
5475932620.692121290.61
6210923551.121901891.00
7595850610.852852620.92
Mean ± SD3966 ± 12683358 ± 9680.87 ± 0.15207 ± 54156 ± 55b0.76 ± 0.16b
  • a AUC, area under the plasma concentration-time curve.

  • b Day 5 parameter was significantly different (P < 0.05) from the corresponding day 1 parameter.