Table 6

Interpatient differences in AUC24ha of etoposide catechol

PatientsAUC (μg·min/ml) Total catechol day 1AUC (μg·min/ml) Total catechol day 5AUC ratio of day 5 to day 1AUC (μg·min/ml) Free catechol day 1AUC (μg·min/ml) Free catechol day 5AUC ratio of day 5 to day 1
164.3114.51.783.564.521.27
233.540.71.221.591.721.08
342.654.21.271.732.191.27
459.8132.82.223.495.121.47
582.9183.22.223.687.271.98
648.686.11.774.376.921.58
760.1125.92.102.886.512.26
Mean ± SD55.9 ± 16.1105.4 ± 49.1b1.80 ± 0.42b3.04 ± 1.044.89 ± 2.23b1.56 ± 0.42b
  • a AUC, area under the plasma concentration-time curve.

  • b Day 5 parameter was significantly different (P < 0.05) from corresponding day 1 parameter.