Table 2

Prevalence of methylated Cyclin D2, RAR-β, Twist, RASSF1A, and HIN-1 in breast cancer metastasis

Prevalence is compared in bone, brain and lung metastasis to prevalence in primary breast cancer using Fisher’s exact test.

TissuenaCyclin D2 (%)PRAR-β (%)PTwist (%)PRASSF1A (%)PHIN-1 (%)P
Primary breast cancer2510/25 (40)9/25 (36)8/25 (32)14/25 (56)10/25 (40)
Bone126/12 (50)0.739/10 (90)<0.015/9 (56)0.257/9 (78)0.429/10 (90)<0.01
Brain87/8 (88)0.046/7 (86)0.035/7 (71)0.094/6 (67)0.997/7 (100)<0.01
Lung76/9 (67)0.257/9 (78)0.056/9 (67)0.1210/10 (100)0.018/8 (100)<0.01
  • a n, number of cases.