Table 2.

Gene expression results from dilutional microarray analysis

Rank*DescriptionsMetastasis1:501:2,5001:125,000N-mix
1mammaglobin 1 (MGB1)6,3481,33538119
2trefoil factor 1, breast cancer, estrogen-inducible sequence expressed in (TFF1)5,4431,013905147
3trefoil factor 3, intestinal (TFF3)4,243195928790
4keratin 19 (KRT19)2,991150922
5PRO17082,941237111212
6lipophilin B, uteroglobin family member, prostatein-like (LPHB)2,819132846
7S100 calcium-binding protein P (S100P)1,852884173
8v-fos FBJ murine osteosarcoma viral oncogene homologue, clone MGC:110741,783220413427
9serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3)1,5141679211982
10Estrogen receptor 1 (ESR1)1,4831918299111
*prolactin-induced protein (PIP)1,37670174149
11Human gastrointestinal tumor-associated antigen GA733-1 protein, clone 055161,29288302328
12v-jun avian sarcoma virus 17 oncogene homologue1,213222135185163
13Prostaglandin D synthase gene1,118717587903845
14cytokeratin 891755675445
15alpha-fetoprotein (AFP)90455282431
*prostate epithelium–specific Ets transcription factor (PDEF)42445171913
*tumor-associated calcium signal transducer 1 (TACSTD1; EpCAM)34618141622
*carcinoembryonic antigen–related cell adhesion molecule 5 (CEACAM5), mRNA328885488116
*Mammaglobin 2 (MGB2), mRNA2512211
  • NOTE: Bolded entries correspond to genes used in the MIMS Trial. Genes that lack a numeric value (*) in the rank category failed to meet the following selection criteria: signal present in 1:50 dilution (PIP, PDEF, EpCam, CEA, and mamB); signal >500 relative units in metastatic tissue (PDEF, EpCam, CEA, and mamB).

  • * Rank value was based on relative intensity of undiluted metastatic signal.