Table 1.

Kinase selectivity of CHIR-258

RTKKinase IC50 (nmol/L)
FMS-like tyrosine kinase 31
KIT2
VEGFR110
VEGFR213
VEGFR38
FGFR18
FGFR39
PDGFRβ27
Colony-stimulating factor receptor36
PDGFRα200
INSR2,100
Epidermal growth factor receptor 12,218
ErbB2>20,000
Raf>25,000