Table 2.

Pharmacokinetic variables of CHIR-258 in KM12L4a tumor-bearing mice

Dose (mg/kg/d)Cmax ng/mL (μmol/L)Area under plasma concentration-time curve (ng h/mL)Trough concentrations* ng/mL (μmol/L)
10163 (0.4)1,4202-4 (0.005-0.01)
30742 (1.9)5,5407-23 (0.02-0.06)
1001,560 (4.0)18,50050-135 (0.13-0.34)
  • * Range of trough concentration values on days 2 to 15.