Table 3.

Target modulation by CHIR-258 in KM12L4a tumors

Dose (mg/kg)% Inhibition of p-PDGFRβ/PDGFRβ% Inhibition of p-ERK/ERK
2 h post-dose
    105752
    305955
    1006256
4 h post-dose
    107864
    307668
    1008270
24 h post-dose
    101512
    304245
    1005349
48 and 72 h post-dose
    1000
    3000
    10000