Table 2.

Allele and genotype distributions of the polymorphisms in the VEGF gene in different populations

Polish
German
Swedish
Joint
Polymorphism/genotypeCases (%)Controls (%)OR* (95% CI)Cases (%)Controls (%)OR* (95% CI)Cases (%)Controls (%)OR* (95% CI)OR* (95% CI)
−2578C/A
CC104 (25.3)106 (25.1)1.0044 (28.8)50 (30.9)1.00258 (27.5)257 (27.3)1.001.00
CA195 (47.4)207 (48.9)0.96 (0.68-1.36)75 (49.0)72 (44.4)1.18 (0.68-2.06)449 (47.8)451 (48.0)0.99 (0.79-1.24)1.00 (0.84-1.19)
AA112 (27.3)110 (26.0)1.04 (0.70-1.54)34 (22.2)40 (24.7)0.97 (0.50-1.86)232 (24.7)232 (24.7)1.00 (0.77-1.29)1.00 (0.82-1.23)
A%51.050.546.746.948.648.7
−1154G/A
GG173 (42.1)199 (47.0)1.0084 (52.8)76 (46.6)1.001.00
GA189 (46.0)178 (42.1)1.22 (0.91-1.65)58 (36.5)69 (42.3)0.76 (0.46-1.25)1.07 (0.83-1.38)
AA49 (11.9)46 (10.9)1.23 (0.76-1.97)17 (10.7)18 (11.0)0.85 (0.39-1.89)1.11 (0.74-1.66)
A%34.931.928.932.2
−634G/C
GG488 (52.1)492 (52.3)1.00
GC363 (38.8)367 (39.0)1.00 (0.82-1.21)
CC85 (9.1)82 (8.7)1.05 (0.74-1.47)
C%28.528.2
+936C/T
CC298 (72.3)297 (70.4)1.00120 (78.4)128 (78.5)1.00708 (76.6)720 (77.1)1.001.00
CT100 (24.3)114 (27.0)0.87 (0.63-1.21)31 (20.3)31 (19.0)1.07 (0.59-1.93)204 (22.1)203 (21.7)1.02 (0.81-1.28)0.98 (0.82-1.17)
TT14 (3.4)11 (2.6)1.27 (0.53-3.05)2 (1.3)4 (2.5)0.53 (0.07-3.46)12 (1.3)11 (1.2)1.11 (0.45-2.71)1.10 (0.62-1.94)
T%15.516.111.412.012.312.0
  • Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

  • * Comparison with the genotype indicated by an odds ratio of 1.00.