Table 4.

Associations of the VEGF haplotypes with tumor characteristics in the Swedish population

Tumor size (mm)
Histologic grade
≤20>20OR for tumor sizePGrade 1Grade 2Grade 3Ptrend
Haplotype
−2578/−634*
    CC263 (26.9)153 (35.0)1.47 (1.15-1.89)0.00260 (23.4)166 (27.6)159 (34.1)0.005
    AG479 (49.0)196 (45.0)0.85 (0.67-1.07)0.18140 (54.6)287 (47.6)208 (44.6)0.04
Haplotype in individuals
No. CC copies in an individual
    0264 (54.0)95 (43.6)1.0075 (58.6)159 (52.8)107 (45.9)
    1187 (38.2)93 (42.7)1.38 (0.97-1.97)0.0846 (35.9)118 (39.2)93 (39.9)0.33
    238 (7.8)30 (13.8)2.19 (1.24-3.86)0.0057(5.5)24 (8.0)33(14.2)0.005
No. AG copies in an individual
    0134 (27.4)71 (32.6)1.0026 (20.3)87 (28.9)75 (32.2)
    1231 (47.2)98 (45.0)0.80 (0.54-1.18)0.2864 (50.0)141 (46.8)108 (46.4)0.15
    2124 (25.4)49 (22.5)0.75 (0.47-1.18)0.2338 (29.7)73 (24.3)50 (21.5)0.04
  • * Comparison with all the other haplotypes.

  • Comparison with the noncarriers of the specific haplotype indicated by an odds ratio of 1.00.