Associations of the VEGF haplotypes with tumor characteristics in the Swedish population
| Tumor size (mm) | Histologic grade | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤20 | >20 | OR for tumor size | P | Grade 1 | Grade 2 | Grade 3 | Ptrend | |||||||||
| Haplotype | ||||||||||||||||
| −2578/−634* | ||||||||||||||||
| CC | 263 (26.9) | 153 (35.0) | 1.47 (1.15-1.89) | 0.002 | 60 (23.4) | 166 (27.6) | 159 (34.1) | 0.005 | ||||||||
| AG | 479 (49.0) | 196 (45.0) | 0.85 (0.67-1.07) | 0.18 | 140 (54.6) | 287 (47.6) | 208 (44.6) | 0.04 | ||||||||
| Haplotype in individuals† | ||||||||||||||||
| No. CC copies in an individual | ||||||||||||||||
| 0 | 264 (54.0) | 95 (43.6) | 1.00 | 75 (58.6) | 159 (52.8) | 107 (45.9) | ||||||||||
| 1 | 187 (38.2) | 93 (42.7) | 1.38 (0.97-1.97) | 0.08 | 46 (35.9) | 118 (39.2) | 93 (39.9) | 0.33 | ||||||||
| 2 | 38 (7.8) | 30 (13.8) | 2.19 (1.24-3.86) | 0.005 | 7(5.5) | 24 (8.0) | 33(14.2) | 0.005 | ||||||||
| No. AG copies in an individual | ||||||||||||||||
| 0 | 134 (27.4) | 71 (32.6) | 1.00 | 26 (20.3) | 87 (28.9) | 75 (32.2) | ||||||||||
| 1 | 231 (47.2) | 98 (45.0) | 0.80 (0.54-1.18) | 0.28 | 64 (50.0) | 141 (46.8) | 108 (46.4) | 0.15 | ||||||||
| 2 | 124 (25.4) | 49 (22.5) | 0.75 (0.47-1.18) | 0.23 | 38 (29.7) | 73 (24.3) | 50 (21.5) | 0.04 | ||||||||