Table 5.

Pharmacokinetic variables for cycle 1 and cycle 2 for the expanded cohorts for which additional pharmacology blood draws were done for CPT and its metabolites

Cycle 1
Cycle 2
CohortCPTCmax (μmol/L)SDAUC (μmol/L/h)SD*Clearance/FM (L/h/m2)SDCmax (μmol/L)SDAUC (μmol/L/h)SDClearance/FM (L/h/m2)SD
Irinotecan1001,928.39412.807.023.7528.4717.281,821.38687.1313.037.5928.4536.04
1252,024.96575.2210.369.2422.1318.563,293.031,271.0017.211.0924.2227.92
SN-3810074.5258.710.400.25856.15449.852.6631.090.600.411,146.221,772.3
12588.2136.180.920.98847.30750.6119.2412.391.261.081,041.001,353.7
SN-38G100178.35208.212.322.11127.4887.2286.5545.492.531.50258.30429.40
125195.86173.305.015.6391.7972.52195.8621.754.053.97234.04302.84
  • * Clearance/FM is the clearance divided by the formation fraction.