Table 1.

Individual prognostic factors

P-cadherin negative (n = 181)P-cadherin positive (n = 80)OR (95% CI)P10-year % survivalNo. eventsP
Age at diagnosis (y)
    <50723164.5320.06
    ≥50109491.04 (0.61-1.79)0.8973.934
Tumor size (cm)
    <2993383.218<0.0001
    ≥273431.77 (1.02-3.05)0.0557.943
Histologic grade*
    1761092.25
    278262.53 (1.14-5.61)0.0365.232<0.0001
    3254413.38 (5.88-30.43)<0.000150.928<0.0001
Lymph node status
    Negative864381.520<0.0001
    Positive79300.76 (0.44-1.33)0.4056.841
ER
    Negative345951.139<0.0001
    Positive147210.08 (0.04-0.15)<0.000180.427
p53
    Negative1534776.239<0.0001
    Positive27333.98 (2.17-7.28)<0.000150.727
HER2
    Negative1646573.6510.001
    Positive17152.23 (1.05-4.72)0.0445.015
KIP1
    Negative935764.1460.002
    Positive75160.35 (0.18-0.66)0.000980.614
Cyclin E
    Negative1483576.037<0.0001
    Positive22448.46 (4.50-15.89)49.828
Cytokeratin 5/6
    Negative12826<0.000175.8320.004
    Positive43536.07 (3.39-10.87)59.032
GMP
    Negative14950<0.000173.6440.0002
    Positive15275.36 (2.64-10.89)48.320
BRCA1/2
    Negative16759<0.000172.453
    BRCA1 mutation8196.72 (2.79-16.17)<0.000157.5100.08
    BRCA2 mutation620.94 (0.19-4.80)0.9953.630.29
KIP1 and Cyclin E
    Cyclin E negative, KIP1 negative63984.59
    Cyclin E negative, KIP1 positive77211.91 (0.82-4.47)0.1671.6240.03
    Cyclin E positive, KIP1 negative1074.90 (1.49-16.14)0.0161.850.10
    Cyclin E positive, KIP1 positive103524.50 (9.10-65.99)043.221<0.0001
  • * P < 0.0001, increasing trend in OR.

  • P < 0.0001, increasing trend in OR of KIP1 by Cyclin E.