Table 3.

Summary of estimated paclitaxel blood pharmacokinetic variables for ABI-007 and Taxol (pharmacokinetic population)

VariableABI-007 260 mg/m2, 30 min (n = 14)
Taxol 175 mg/m2, 3 h (n = 12)
P
Mean% Coefficient of variationRangeMean% Coefficient of variationRange
CL (L/h·m2)21.1343.88.72-43.4114.7631.810.20-28.750.048
Vss (L/m2)230.754.353.2-492.9156.343.299.7-346.00.211
Vz (L/m2)663.848.1296.3-1,347.3433.431.1308.7-809.70.040
AUC (ng/h·mL)14,788.645.35,981.7-28,680.212,602.721.06,087.1-17,081.20.524
AUC∞da (ng/h·mL)56.8446.323.04-114.771.9021.134.78-98.000.049
Cmax (ng/mL)22,968.6112.54,060-86,7003,543.357.21,540-9,380<0.001
Cmaxda (ng/mL)88.69114.215.64-346.820.1455.88.8-52.4<0.001
Tmax (h)0.3645.20-0.52.6527.61.0-3.5<0.001
λz (h−1)0.03316.90.023-0.0420.03413.00.026-0.0400.477
t1/2 (h)21.617.216.5-29.620.514.617.5-26.30.479
AUC∞%extrap (%)2.841.31.0-5.02.852.61.4-6.80.983