Table 1

Relationship of histologic subtypes with aberrant expr0ession of cell cycle proteins

Adenocarcinoma, n (%)SQCC, n (%)LCC, n (%)
Cyclin D1+24/54 (44)17/29 (59)9/22 (41)
pRb−10/52 (19)1/29 (3)*7/22 (32)
p16INK4A27/49 (55)10/26 (39)14/21 (67)
p21Waf1+23/55 (42)12/29 (48)10/22 (46)
p53+23/54 (43)17/29 (59)13/22 (59)
  • NOTE: +, immunopositive for p16INK4A and pRb and overexpression of cyclin D1, p21Waf1, and p53; −, immunonegative for p16INK4A and pRb and negative for overexpression of cyclin D1, p21Waf1, and p53.

  • * P = 0.02.

  • P = 0.05.