Table 2

Relationship of p53 mutations with aberrant expression of cell cycle proteins

No p53 mutation, n (%)Non-G:C to T:A, n (%)G:C to T:A, n (%)
Cyclin D1+22/47 (47)12/30 (40)10/15 (67)*
pRb−9/46 (20)7/29 (24)1/13 (77)
p16INK4A23/44 (52)13/26 (50)6/13 (46)
p21Waf1+18/47 (38)11/30 (37)9/15 (60)
  • NOTE: +, immunopositive for p16INK4A and pRb and overexpression of cyclin D1, p21Waf1, and p53; −, immunonegative for p16INK4A and pRb and negative for overexpression of cyclin D1, p21Waf1, and p53.

  • * P = 0.2.

  • P = 0.4.