Table 2.

Pharmacokinetic variables of free epigallocatechin gallate after oral administration of Polyphenon E in the absence or presence of food

Pharmacokinetic variablesPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
AUC (min · μg/mL)36.70 ± 24.66*126.96 ± 47.0290.89 ± 37.39254.48 ± 214.21299.40 ± 285.86685.53 ± 394.33
Cmax (ng/mL)141.8 ± 89.1798.7 ± 573.1294.0 ± 113.51,522.4 ± 1,357.8923.6 ± 755.33,371.6 ± 1,651.2
Tmax (min)122.90 ± 83.7093.90 ± 58.99154.90 ± 78.3183.30 ± 31.04175.10 ± 74.5890.60 ± 28.37
CL/F (L/min)14.53 ± 7.843.64 ± 1.5511.63 ± 9.254.80 ± 2.697.39 ± 4.862.37 ± 1.32
Vd/F (L)2,872.8 ± 2,672.8912.4 ± 695.63,112.9 ± 2,810.8946.6 ± 558.32,825.1 ± 2,257.7664.0 ± 223.5
t1/2 (min)145.2 ± 129.1170.5 ± 104.6220.9 ± 209.3156.5 ± 77.5254.9 ± 59.9§228.4 ± 75.3
  • * Mean ± one SD.

  • Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.

  • Significantly different from the fed condition, P < 0.0005 when data were pooled from all doses.

  • § Significantly different from 400 mg dose of the same dosing condition, P < 0.005.