Table 3.

Maximum plasma free catechin concentrations (ng/mL) after oral administration of Polyphenon E in the absence or presence of food

CatechinPolyphenon E (400 mg epigallocatechin gallate)
Polyphenon E (800 mg epigallocatechin gallate)
Polyphenon E (1,200 mg epigallocatechin gallate)
FedFastingFedFastingFedFasting
Epigallocatechin15.9 ± 16.4*39.7 ± 44.634.1 ± 20.374.3 ± 70.042.9 ± 36.7131.0 ± 94.2
Epicatechin1.6 ± 3.95.6 ± 7.82.8 ± 5.01.9 ± 3.410.1 ± 15.316.6 ± 30.0
Epigallocatechin gallate141.8 ± 89.1798.7 ± 573.1294.0 ± 113.51,522.4 ± 1,357.8923.6 ± 755.33,371.6 ± 1,651.2
Epicatechin gallate15.7 ± 8.887.6 ± 62.033.9 ± 11.0174.4 ± 141.1112.9 ± 88.2382.6 ± 176.0
  • * Mean ± one SD.

  • Significantly different from the fed condition, P < 0.001 when data were pooled from all doses.

  • Significantly different from the fed condition, P < 0.0001 when data were pooled from all doses.