Table 1

Kinase selectivity data for MLX105

KinaseIC50 (μmol/L)KinaseIC50 (μmol/L)
AURORA-A>100MAPKAPK2>100
CAMKII>100P38>100
CDK2/cyclinE>100PHOSK>100
CKII22PKA>100
DNA-PK12PKC-α98
ERK2>100PLK>300
GSK3>100PRAK>100
IKK20.025P70S6K>100
JNK1-CJUN>100ROKA>100
LCK>100SGK1>100