Table 2.

Candidate biomarkers predictive of CCRCC aggressive behavior

Gene IddChip-RPAM-RSNR-RTotal rankDescription
FLJ325351212740butyrophilin 3, oc 34c06.s1
BIRC52118140Baculoviral IAP rep-cont. 5 (survivin)
PPP2CA2514241protein phosphatase 2 (formerly 2A), catalytic subunit, α isoform
xs04h08.x1316542null
ECRG4464353esophageal cancer related gene 4 protein
FILIP120211859filamin A interacting protein 1
EPAS1186069endothelial PAS domain protein 1
SCN4B3438779sodium channel, voltage-gated, type IV, beta
PTPRB627280protein tyrosine phosphatase,receptor type, B
SDPR23114781serum deprivation response (phosphatidylserine binding protein)
7n51g03.×119373490null
SHANK311137397SH3 and multiple ankyrin repeat domains 3
EMCN334926108endomucin
ARG99386210110ARG99 protein
TEK393042111TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous, and mucosal)
SYNPO2284145114synaptopodin 2
wa07c11.×110799116null
AL70353243758126null
SAA2566015131serum amyloid A2
MAPT477313133microtubule-associated protein tau
HSPC150428128151HSPC150 protein similar to ubiquitin-conjugating enzyme
PLN635038151Phospholamban
PDZK3366353152PDZ domain containing 3
ERG14146100160v-ets erythroblastosis virus E26 oncogene like (avian)
CKS2155293160CDC28 protein kinase regulatory subunit 2
IL8994223164IL-8
tb28a05.×1409835173tb28a05.x1
LDB21644115175LIM domain binding 2
DKFZP564O0823746836178DKFZP564O0823 protein, tu03g12.x1
NPY1R3536109180neuropeptide Y receptor Y1
BF5083441865112195null
FLJ226558010514199hypothetical protein FLJ22655
yc17g11.s1327989200null
NX17377691204kidney-specific membrane protein
  • NOTE: dChip-R, PAM-R, and SNR-R denote the rankings by dChip (based on fold change and P), PAM, and signal-to-noise ratio, respectively. Total rank denotes the sum of the three rankings. Up-regulated genes in aggressive primary and metastatic CCRCC compared with nonaggressive primaries are in bold letters.