Criteria for CDH1 mutation testing modified to reflect current data
| Modified testing criteria | 1. Family with two or more cases of gastric cancer, with at least one DGC diagnosed before the age of 50. (>30%)* |
| 2. Family with multiple LBC with or without DGC in first-degree relatives (unknown)* | |
| 3. Isolated individual diagnosed with DGC at <35 y from a low-incidence population (>10%)* | |
| 4. Isolated personal history of both DGC and LBC (unknown)* | |
| Potential additional criteria | 5. Family with three or more cases of gastric cancer diagnosed at any age one or more of which is a documented case of DGC; no other criteria met (such families are extremely rare) |
| 6. Family with one or more cases of both DGC and signet ring colon cancer (this association is unproven) |
↵* Percentage of expected positive results.