Table 1.

Genetic alterations of hMLH1 protein/gene in relation to the clinicopathologic variables of resected nonsmoking female lung cancer tumors

CharacteristicsProtein expression
DNA hypermethylation
Total+* (%)PTotal+* (%)P
Overall1053570 (66.7)1053570 (66.7)
Age (mean ± SD)61.2 ± 1159.4 ± 130.47561.6 ± 1159.4 ± 130.324
Age
    >60572235 (61.4)0.213572334 (59.6)0.096
    ≤60481335 (72.9)481236 (75.0)
Tumor type
    AD652243 (66.2)0.457652243 (66.2)0.919
    SQ17413 (76.5)17611 (64.7)
    AS202 (100.0)211 (50.0)
    Other21912 (57.1)21615 (71.4)
Tumor stage
    I + II611942 (68.9)0.576611942 (68.9)0.576
    III + IV441628 (63.6)441628 (63.6)
Protein expression
    +352114 (40.0)0.00004
    −701456 (80.0)
  • Abbreviations: AD, adenocarcinoma; SQ, squamous carcinoma; AS, adenosquamous carcinoma.

  • * These groups represent patients with alteration in the hMLH1 gene/protein.

  • The comparison was made between SQ and AD.