Multivariate analysis of predictive factors for pathologic CR
| Variables | Model 1: clinical and histologic variables | Model 2: clinical variables and molecular classification | Model 3: clinical, histologic variables, molecular classification | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||||||
| Age (y) | ||||||||||||
| <50 | 1 | 1 | 1 | |||||||||
| >50 | 0.27 (0.8-0.91) | 0.035 | 0.17 (0.06-0.45) | <0.001 | 0.43 (0.11-1.7) | 0.43 | ||||||
| Tumor (cm) | ||||||||||||
| <5 | 1 | 1 | 1 | |||||||||
| >5 | 0.55 (0.14-2.3) | 0.41 | 0.53 (0.15-1.8) | 0.28 | 0.64 (0.14-2.9) | 0.56 | ||||||
| Node | ||||||||||||
| N0 | 1 | 1 | 1 | |||||||||
| N1-3 | 0.96 (0.31-3.0) | 0.94 | 0.65 (0.22-2.0) | 0.18 | 0.90 (0.22-3.7) | 0.90 | ||||||
| Estrogen receptor | ||||||||||||
| Negative | 1 | 1 | ||||||||||
| Positive | 0.12 (0.02-0.31) | <0.001 | 0.08 (0.02-0.35) | 0.001 | ||||||||
| HER-2 | ||||||||||||
| Negative | 1 | 1 | ||||||||||
| Positive | 1.77 (0.42-7.5) | 0.43 | 0.32 (0.03-3.6) | 0.34 | ||||||||
| Nuclear grade | ||||||||||||
| 1/2 | 1 | 1 | ||||||||||
| 3 | 2.6 (0.81-8.4) | 0.11 | 2.5 (0.4-13.6) | 0.30 | ||||||||
| Histology | ||||||||||||
| Ductal | 1 | 1 | ||||||||||
| Other | 1.14 (0.17-7.5) | 0.89 | 2.3 (0.11-1.7) | 0.76 | ||||||||
| Molecular classification | ||||||||||||
| Luminal/normal-like | 1 | 1 | ||||||||||
| Normal-like | 0 (0-…) | 0.99 | 0 (0-…) | 0.99 | ||||||||
| Basal-like | 3.3 (1.0-11) | 0.06 | 0.8 (0.12-5.5) | 0.83 | ||||||||
| erbB2+ | 4.4 (1.2-17) | 0.026 | 7.8 (0.62-100) | 0.11 | ||||||||
NOTE: Multivariate analysis of different combinations of clinical (age, tumor, node) and histopathologic characteristics (grade, estrogen receptor and HER-2 status, and histologic type) and molecular class as variables. Three distinct prediction models were examined: clinical plus histopathologic variables (model 1), clinical variables plus molecular class (model 2), and all three types of information together (model 3).