Table 1.

Induction of apoptosis in CD20+ and CD20 cell lines by Rituximab monomer, dimer, and polymer preparations

Lymphoma cell linesCD20 expression (MFI*)UntreatedRituximabRituximab dimerRituximab polymer
CD20+
    Raji514.344.5627.8626.9766.07
    B35M349.336.0213.138.9256.36
    RAMOS374.445.047.666.0824.68
    SU-DHL-4672.194.7810.677.3111.54
    SU-DHL-6685.6428.1645.3642.5055.89
    SU-DHL-10631.977.0127.8525.6936.88
    SU-DHL-16585.1415.0727.2823.0631.43
    Farage643.6319.2221.2520.5646.11
    Granda 519495.4811.7820.2718.6148.30
    Chevallier408.9918.1818.8016.8040.70
CD20
    DG-75180.786.828.046.857.85
    L540196.3716.2316.5416.0216.00
  • * Mean fluorescence intensity.

  • Percent nonviable cells.