Table 3.

Association between the ERCC1 codon 118 polymorphism and the response to chemotherapy

Chemotherapy regimensGlobal
T/T group
C/T group
C/C group
P
Number of treatments
Objective responses
Number of treatments
Objective responses
Number of treatments
Objective responses
Number of treatments
Objective responses
nn (%)nn (%)nn (%)nn (%)
5-FU5319 (35.8)209 (45.0)247 (29.2)93 (33.3)0.407
Oxaliplatin + 5-FU6127 (44.3)2113 (61.9)2611 (42.3)143 (21.4)0.018
Irinotecan + 5-FU4013 (32.5)136 (46.1)164 (25.0)113 (27.3)0.305
All regimens15459 (38.3)5428 (51.8)6622 (33.3)349 (26.5)
  • NOTE: The objective response corresponded to a complete (disappearance of the disease) or a partial (>50% reduction in tumor load of the lesions) response to the various treatments.