Table 4.
A. Risk of gastric carcinoma associated with the IL-8 −251 genotypes and allele frequencies
IL-8 genotypeControls (n = 308)Gastric cancer cases (n = 470)OR (95% CI)P
AA, n (%)62 (20.1)59 (12.6)1.00
AT, n (%)138 (44.8)213 (45.3)1.62 (1.07-2.46)0.022
TT, n (%)108 (35.1)198 (42.1)1.93 (1.26-2.95)0.002
0.004 (trend test)
T allele (%)57.564.8
A allele (%)42.535.2
B. Risk of noncardia gastric carcinoma associated with the IL-8 −251 genotypes and H. pylori infection
IL-8 genotypeH. pylori negative
H. pylori positive

Controls (n = 166)
Gastric cancer cases (n = 133)
OR (95% CI)
Controls (n = 114)
Gastric cancer cases (n = 231)
OR (95% CI)
AA31171.025271.0
AT74581.43 (0.72-0.83)*531061.85 (0.98-3.50)
TT61581.73 (0.87-3.46)36982.52 (1.30-4.90)§
AT + TT1351161.57 (0.83-2.98)892042.12 (1.17-3.86)
  • NOTE: In part A, χ2 = 9.239; P = 0.010 for genotype distribution; χ2 = 8.453; P = 0.004 for allele frequency. The observed genotype frequency in the control subjects was in agreement with Hardy-Weinberg equilibrium (p2 + 2pq + q2 = 1; χ2 = 0.977; P = 0.641).

  • * χ2 = 1.052; P = 0.305.

  • χ2 = 3.655; P = 0.056.

  • χ2 = 2.454; P = 0.117.

  • § χ2 = 7.647; P = 0.006.

  • χ2 = 1.903; P = 0.168.

  • χ2 = 6.255; P = 0.012.