Table 7.
A. Genotype frequencies of IL-8 promoter −251A/T according to histologic types and anatomic sites of gastric carcinoma
AA (%)AT (%)TT (%)AT + TT (%)Total cases
Histologic type*
    Intestinal28 (19.5)61 (42.7)54 (37.8)115 (80.5)143
    Diffuse8 (9.1)42 (47.7)38 (43.2)80 (90.9)88
    Mixed11 (10.2)53 (49.1)44 (40.7)97 (89.8)108
    Total cases339
Location
    Cardia11 (11.9)39 (42.4)42 (45.7)92
    Noncardia48 (12.7)174 (46.0)156 (41.3)378
    Total cases470
B. Stratification analysis of IL-8 −251 A/T genotypes by histologic types
GenotypesControls (n = 308)Intestinal
Diffuse§
Mixed


Cases (n = 143)
OR (95% CI)
Cases (n = 88)
OR (95% CI)
Cases (n = 108)
OR (95% CI)
AA62281.0081.00111.00
AT138610.99 (0.57-1.68)422.36 (1.05-5.32)532.16 (1.06-4.43)**
TT108541.11 (0.64-1.92)382.73 (1.20-6.22)††442.30 (1.11-4.77)‡‡
AT + TT2461151.04 (0.63-1.70)802.52 (1.16-5.49)§§972.22 (1.12-4.40)∥∥
  • NOTE: In part A, among the 470 patients with gastric carcinoma, 339 received surgical treatment and were subjected to Laurén classification of histopathology.

  • * Genotype distributions AT versus TT: χ2 = 0.092: P = 0.955; AA versus AT + TT: χ2 = 6.816; P = 0.033.

  • Mixed-type represented gastric carcinoma containing both intestinal and diffuse entities.

  • Genotype distribution for cardia versus noncardia: χ2 = 0.586; P = 0.746.

  • § P = 0.026, trend test.

  • P = 0.050, trend test.

  • χ2 = 4.464; P = 0.035.

  • ** χ2 = 4.624; P = 0.032.

  • †† χ2 = 6.016; P = 0.014.

  • ‡‡ χ2 = 5.143; P = 0.023.

  • §§ χ2 = 5.732; P = 0.017.

  • ∥∥ χ2 = 5.466; P = 0.019.