Table 2.

EphB2 expression in human tumors (percentage values)

Tumor entityEphrin receptor immunostaining
nWeak (%)Moderate (%)Strong (%)
Skin tumors
    Skin, basalioma446.80.00.0
    Skin, benign appendix tumor313.20.00.0
    Skin, benign nevus470.00.00.0
    Skin, Merkel cell cancer520.00.00.0
    Skin, malignant melanoma4912.20.00.0
    Skin, squamous cell cancer450.00.00.0
Respiratory tract tumors
    Oral cavity, squamous cell carcinoma424.80.00.0
    Larynx, squamous cell carcinoma3010.00.00.0
    Lung, squamous cell carcinoma500.02.00.0
    Lung, adenocarcinoma500.02.04.0
    Lung, large cell cancer492.02.00.0
    Lung, small-cell cancer482.10.00.0
    Malignant mesothelioma1513.313.30.0
    Pharynx, lymphoepithelial carcinoma50.00.00.0
Gynecologic tumors
    Breast, apocrine cancer30.00.00.0
    Breast, cribriform cancer60.00.00.0
    Breast, ductal cancer490.00.00.0
    Breast, lobular cancer430.00.00.0
    Breast, medullary cancer293.40.00.0
    Breast, mucinous cancer273.70.00.0
    Breast, Phylloides tumor1010.00.00.0
    Breast, tubular cancer250.00.00.0
    Ovary, dysgerminoma20.00.00.0
    Ovary, gonadoblastoma10.00.00.0
    Ovary, yolk sack tumor10.00.00.0
    Ovary, undifferentiated carcinoma10.00.00.0
    Ovary, Brenner tumor10.00.00.0
    Ovary, serous cancer4910.26.12.0
    Ovary, mucinous cancer214.80.00.0
    Ovary, endometroid cancer5010.02.02.0
    Vagina, squamous cell cancer540.00.00.0
    Vulva, squamous cell cancer430.00.00.0
    Uterus cervix, squamous cell carcinoma320.00.03.1
    Uterus, cervix, CIN III170.00.00.0
    Uterus, cervix, adenocarcinoma333.30.00.0
    Uterus, carcinosarcoma50.00.00.0
    Endometrium, endometroid carcinoma496.10.02.0
    Endometrium, serous carcinoma2330.44.30.0
    Endometrioid stroma sarcoma425.00.00.0
Digestive tract tumors
    Salivary gland, pleomorphic adenoma486.30.00.0
    Salivary gland, cylindroma533.80.00.0
    Salivary gland, adenolymphoma300.00.00.0
    Salivary gland, small-cell cancer1100.00.00.0
    Salivary gland, acinus cell cancer714.30.00.0
    Salivary gland, squamous cell cancer20.00.00.0
    Salivary gland, unclassified carcinoma10.00.00.0
    Salivary gland, undifferentiated carcinoma60.00.00.0
    Salivary gland, mucoepidermoid cancer50.00.00.0
    Salivary gland, adenocarcinoma20.00.00.0
    Esophagus, adenocarcinoma616.70.016.7
    Esophagus, squamous cell carcinoma313.20.03.2
    Esophagus, small-cell carcinoma10.00.00.0
    Stomach, diffuse adenocarcinoma2114.34.80.0
    Stomach, intestinal adenocarcinoma4320.97.02.3
    Small intestine, adenocarcinoma1040.020.010.0
    Colon adenoma, mild dysplasia4221.426.252.4
    Colon adenoma, moderate dysplasia414.929.365.9
    Colon adenoma, severe dysplasia355.728.665.7
    Colon, adenocarcinoma454.413.315.6
    Anus, squamous cell cancer333.30.00.0
    GIST316.50.00.0
    Gall bladder, adenocarcinoma2119.00.00.0
    Hepatocellular carcinoma468.72.20.0
    Pancreas, adenocarcinoma4621.72.22.2
Genitourinary tract tumors
    Kidney, clear cell cancer472.10.00.0
    Kidney, chromophobic cancer120.00.00.0
    Kidney, papillary cancer466.50.02.2
    Kidney, oncocytoma1010.00.00.0
    Urinary bladder cancer, TCC noninvasive (pTa)456.70.00.0
    Urinary bladder cancer, cancer, TCC invasive (pT2-4)405.00.00.0
    Urinary bladder, squamous cell cancer812.50.00.0
    Urinary bladder, small-cell cancer40.00.00.0
    Urinary bladder, sarcomatoid cancer80.00.00.0
    Urinary bladder, adenocarcinoma40.00.00.0
    Urinary bladder, inverted carcinoma10.00.00.0
    Prostate cancer, untreated550.01.80.0
    Prostate cancer, hormone refractory319.70.00.0
    Testis, mixed cancer20.00.00.0
    Testis, seminoma502.00.00.0
    Testis, nonseminomatous cancer545.60.00.0
    Testis, teratoma60.00.00.0
    Penile cancer320.00.00.0
Neuroendocrine tumors
    Adrenal gland, adenoma1533.30.00.0
    Adrenal gland, cancer60.00.00.0
    Paraganglioma90.011.10.0
    Pheochromocytoma300.00.00.0
    Thyroid, adenoma4420.50.00.0
    Thyroid, follicular cancer480.00.02.1
    Thyroid, papillary cancer378.10.00.0
    Thyroid, anaplastic cancer50.00.00.0
    Thyroid, medullary cancer80.00.00.0
    Parathyroid, adenoma240.00.00.0
    Parathyroid, cancer10.00.00.0
    Carcinoid tumor449.10.00.0
Hematologic neoplasias
    NHL, diffuse large B224.54.50.0
    NHL, others303.33.30.0
    MALT lymphoma480.04.22.1
    Hodgkin lymphoma, nodular sclerosis355.70.00.0
    Hodgkin lymphoma, mixed cell190.00.00.0
    AML10.00.00.0
    CML50.00.00.0
    Thymoma240.00.00.0
Brain tumors
    Meningeoma488.34.20.0
    Astrocytoma402.52.50.0
    Glioblastoma multiforme484.22.14.2
    Oligodendroglioma296.93.40.0
    Medulloblastoma50.00.040.0
    Esthesioneuroblastoma250.00.050.0
    Craniopharyngeoma290.00.00.0
    Ependymoma80.00.00.0
Soft tissue tumors
    Lipoma110.00.00.0
    Liposarcoma2910.30.00.0
    Benign histiocytoma280.00.00.0
    Dermatofibroma protuberans425.00.00.0
    Malignant fibrous histiocytoma296.93.40.0
    Leiomyoma590.00.00.0
    Leiomyosarcoma4012.50.00.0
    Alveolar sarcoma10.00.00.0
    Rhabdomyosarcoma1414.30.00.0
    Fibrosarcoma922.20.00.0
    Tendon sheath, giant cell tumor352.90.00.0
    Synovial sarcoma333.333.333.3
    Epitheloid sarcoma20.00.00.0
    Epitheloid hemangioma10.00.00.0
    Glomus tumor60.00.00.0
    Capillary hemangioma270.00.00.0
    Hemangiopericytoma90.011.111.1
    Angiosarcoma40.00.00.0
    Kaposi sarcoma263.80.00.0
    Neurofibroma400.00.00.0
    Ganglioneuroma70.00.00.0
    Granular cell tumor80.00.00.0
    Schwannoma490.00.00.0
    Malignant Schwannoma80.00.00.0
    Angiomyolipoma10.00.00.0
    Opticus glioma10.00.00.0
    PNET1717.60.00.0
    Adenomatoid tumor1020.00.00.0
  • Abbreviations: CIN, cervical intraepithelial neoplasia; GIST, gastrointestinal stromal tumor; TCC, transitional cell carcinoma; NHL, non-Hodgkin's lymphoma; MALT, mucosa-associated lymphatic tissue lymphoma; AML, acute myelogenous leukemia; CML, chronic myelogenous leukemia; PNET, primitive neuroectodermal tumor.