Table 1.

Effects of ketoconazole on the formation of SN-38 and SN-38G in human hepatocytes

SN-38/IS (×10−3)
SN-38G/IS (×10−3)
SN-38G/SN-38
ControlKetoconazole
ControlKetoconazole
ControlKetoconazole
1.6 μmol/L16 μmol/L1.6 μmol/L16 μmol/L1.6 μmol/L16 μmol/L
Irinotecan (10 μmol/L)9.7 ± 0.113.3 ± 0.19.4 ± 0.126.9 ± 0.316.4 ± 1.41.9 ± 0.42.81 ± 0.051.25 ± 0.020.67 ± 0.01
Irinotecan (100 μmol/L)64.4 ± 4.870.0 ± 3.663.5 ± 5.785.2 ± 7.246.9 ± 3.213.7 ± 1.91.31 ± 0.010.66 ± 0.010.21 ± 0.01
  • NOTE: Data are presented as mean ± SE (n = 2).

    Abbreviation: IS, internal standard.