Table 2.

Baseline characteristics according to Annexin A8 group

FactorAnnexin A8
Negative, n (%)Weak, n (%)Strong, n (%)Total, n (%)P
BRE grade
    1299 (25.1)92 (25.7)8 (9.6)399 (24.5)<0.0001
    2526 (44.2)133 (37.2)19 (22.9)678 (41.6)
    3365 (30.7)133 (37.2)56 (67.5)554 (34.0)
Tumor size (cm)
    ≤2412 (35.5)134 (38.0)25 (30.9)571 (35.7)0.44
    >2750 (64.5)219 (62.0)56 (69.1)1,025 (64.2)
    Missing*285235
Nodal status
    Negative472 (48.3)162 (55.5)35 (48.6)669 (49.9)0.09
    Positive506 (51.7)130 (44.5)37 (51.4)673 (50.1)
    Missing*2126611289
Age (y)
    <55352 (29.6)106 (29.7)33 (39.8)491 (30.2)0.15
    ≥55836 (70.4)251 (70.3)50 (60.2)1,137 (69.8)
    Missing*2103
ER status
    Negative220 (19.1)101 (28.9)67 (85.9)388 (24.6)<0.0001
    Positive930 (80.9)249 (71.1)11 (14.1)1,190 (75.4)
    Missing*408553
EGFR status
    Negative1,063 (94.8)309 (89.1)44 (54.3)1,416 (91.4)<0.0001
    Weak/moderate31 (2.8)21 (6.1)15 (18.5)67 (4.3)
    Strong27 (2.4)17 (4.9)22 (27.2)66 (4.3)
    Missing*6911282
CK5 status
    Negative1,105 (97.2)320 (92.0)40 (49.4)1,465 (93.6)<0.0001
    Positive32 (2.8)28 (8.0)41 (50.6)101 (6.4)
    Missing*5310265
Histology
    Adenoid cystic0 (0.0)0 (0.00)1 (1.20)1 (0.06)
    Apocrine9 (0.76)3 (0.84)0 (0.00)12 (0.74)
    Atypical medullary2 (0.17)1 (0.28)1 (1.20)4 (0.25)
    Carcinosarcoma1 (0.08)0 (0.00)0 (0.00)1 (0.06)
    Clear cell11 (0.92)1 (0.28)0 (0.00)12 (0.74)
    Cribriform34 (2.86)9 (2.51)3 (3.61)46 (2.82)
    Ductal854 (71.76)248 (69.27)55 (66.27)1,157 (70.94)
    Histiocytic1 (0.08)0 (0.00)0 (0.00)1 (0.06)
    Lipid rich2 (0.17)0 (0.00)0 (0.00)2 (0.12)
    Lipid rich or histiocytoic2 (0.17)0 (0.00)0 (0.00)2 (0.12)
    Lobular178 (14.96)36 (10.06)5 (6.02)219 (13.43)
    Medullary21 (1.76)18 (5.03)11 (13.25)50 (3.07)
    Metaplastic0 (0.00)3 (0.84)3 (3.61)6 (0.37)
    Mucinous30 (2.52)20 (5.59)2 (2.41)52 (3.19)
    Neuroendocrine0 (0.00)1 (0.28)0 (0.00)1 (0.06)
    Papillary14 (1.18)8 (2.23)2 (2.41)24 (1.47)
    Signet ring1 (0.08)0 (0.00)0 (0.00)1 (0.06)
    Small cell2 (0.17)0 (0.00)0 (0.00)2 (0.12)
    Tubular28 (2.35)10 (2.79)0 (0.00)38 (2.33)
Histology
    Medullary21 (1.76)18 (5.03)11 (13.25)50 (3.07)<0.0001
    Nonmedullary1,169 (98.24)340 (94.97)72 (86.75)1,581 (96.93)
Histology
    Lobular178 (14.96)36 (10.06)5 (6.02)219 (13.43)0.007
    Nonlobular1,012 (85.04)322 (89.94)78 (93.98)1,412 (86.57)
All patients1,190 (100.0)358 (100.0)83 (100.0)1,631 (100.0)
  • Abbreviations: BRE, Bloom, Richardson, Elston; EGFR, epidermal growth factor receptor.

  • * Cases with missing information are not included in tests for significance and percentages.

  • χ2.