Table 2.

Univariate and multivariate Cox proportional hazard analyses

VariableUnivariate HR (95% confidence interval)Multivariate HR (95% confidence interval)
Age (continuous)*0.98 (0.96-1.01)
African American versus Whites1.79 (1.01-3.16)
Log (preoperative PSA), ng/mL1.86 (1.42-2.45)1.12 (0.80-1.57)
Gleason score
    ≤61.001.00
    7(3 + 4)2.25 (0.72-7.05)2.10 (0.57-7.74)
    7(4 + 3)5.04 (1.73-14.72)3.89 (1.11-13.68)
    ≥817.47 (6.34-48.11)10.00 (2.87-34.88)
Pathologic stage, T3 (versus T1/T2)*4.83 (3.16-7.39)
Extraprostatic extension (versus organ confined)4.47 (2.89-6.91)1.70 (0.96-3.02)
Seminal vesicle invasion, yes (versus no)5.46 (3.52-8.47)1.52 (0.86-2.70)
Positive surgical margins (versus negative)3.04 (1.96-4.72)1.49 (0.91-2.45)
Lymph node positive (versus negative)4.58 (2.21-9.47)1.57 (0.66-3.73)
Positive family history (versus negative)*1.54 (0.99-2.41)
Obese at age 25 (versus nonobese)*2.31 (1.01-5.30)
Obese at age 40 (versus nonobese)*2.35 (1.43-3.86)
Obese at diagnosis (versus nonobese)*1.41 (0.91-2.18)
BMI at diagnosis (continuous)1.07 (1.02-1.12)1.07 (1.02-1.13)
Weight change age 25 to diagnosis (continuous)*1.62 (1.00-2.61)
Weight change age 25 to diagnosis* (kg/y)
    Gain, <0.51.00
    Gain, 0.5-1.51.05 (0.66-1.69)
    Gain, >1.52.32 (1.06-5.08)
Physical activity*
    ≥1 times/wk1.00
    Few times/mo1.12 (0.57-2.17)
    Rarely/never0.90 (0.51-1.58)
  • * Dropped from multivariate model.