Table 1.

Responses of pediatric solid tumors to ixabepilone

TumorDose (mg/kg)Mice/groupTime to 4× volume (wk ± SD)PPRCRMCR
Rhabdomyosarcoma
    Rh18071.8 ± 0.4
1079.0 ± 2.3<0.001342
    Rh30072.0 ± 0.0
1077.8 ± 2.20.002151
6.677.1 ± 1.90.002220
4.473.6 ± 0.50.002000
    Rh36072.6 ± 0.5
107>120.001077
Neuroblastoma
    NB1382072.0 ± 0.0
107>120.005076
6.67>120.005076
4.474.8 ± 2.00.014120
    NB1643072.0 ± 0.0
10711.0±0.00.079510
4.467.8 ± 2.60.222120
    NB1691061.8 ± 0.4
1075.4 ± 1.70.002000
4.471.9 ± 0.90.948010
    NB7051.3 ± 0.5
105>120.008055
6.655.0 ± 2.90.151200
4.454.3 ± 0.60.032010
    NB8052.0 ± 0.0
1052.0 ± 0.01.000000
6.653.0 ± 0.00.008000
4.452.2 ± 0.80.444000
Osteosarcoma
    OS1053.2 ± 0.4
105>120.008055
    OS20104.2 ± 0.4
15108.1 ± 1.90.001130
1096.9 ± 1.30.004000
    OS17052.4 ± 0.5
1552.3 ± 0.50.432000
1053.4 ± 0.70.042100
    OS21052.6 ± 0.5
15103.1 ± 0.30.238000
10102.9 ± 0.30.505000
6.62.6 ± 0.51.00000
    OS29054.3 ± 2.2
1059.0 ± 0.00.003110
6.654.4 ± 0.50.564010
4.458.6 ± 1.80.024210
    OS330102.5 ± 0.7
15107.4 ± 0.7<0.001140
10105.6 ± 1.2<0.001100
Wilms' tumor
    WT5053.0 ± 1.2
10109.5 ± 1.00.008140
6.6103.8 ± 0.80.685000
4.4104.0 ± 1.20.907000
    WT6055.6 ± 0.5
105>120.008055
6.659.3 ± 2.90.008020
4.459.5 ± 1.30.008000
    WT8054.8 ± 0.4
105>120.008055
6.654.2 ± 0.80.175000
    WT9052.2 ± 0.4
105>120.008055
6.654.0 ± 0.80.016020
4.453.5 ± 1.30.103000
    WT10052.0 ± 0.0
1053.0 ± 1.20.074000
6.656.0 ± 2.50.024030
4.455.8 ± 1.80.008030
    WT11052.0 ± 0.0
1058.5 ± 2.10.008143
    SKNEP051.2 ± 0.4
105>120.008055
4.453.0 ± 0.70.016000
  • Abbreviations: PR, partial response; CR, complete response; MCR, maintained complete response.