Table 2.

Responses of brain tumor xenografts to ixabepilone

Brain tumorsDose (mg/kg)Mice/groupTime to 4× volume (wk ± SD)PPRCRMCR
GBM2074.9 ± 0.4
1077.0 ± 1.00.001130
GBM2074.7 ± 1.0
1076.3 ± 2.40.245200
BT27072.0 ± 0.0
107>120.001166
4.479.0 ± 0.00.008052
BT29053.0 ± 0.8
1055.8 ± 1.50.040000
BT35052.0 ± 0.0
155>120.008054
105>120.008054
BT36079.5 ± 3.5
107>120.192074
6.677.0 ± 0.01.000010
4.476.5 ± 0.70.841010
BT37072.7 ± 0.5
1578.0 ± 0.00.001251
107>120.001164
6.676.3 ± 1.50.001110
4.475.3 ± 0.60.001000
BT40072.7 ± 0.5
1075.8 ± 0.40.001000
6.675.8 ± 2.20.001110
4.475.2 ± 2.60.005010
BT41058.0 ± 1.9
1057.5 ± 2.10.198050
BT48052.0 ± 0.7
1553.2 ± 0.40.040000
  • Abbreviations: PR, partial response; CR, complete response; MCR, maintained complete response.