Table 3.

Pharmacokinetic parameters of ixabepilone in mice

Parameter (unit)
Dose (mg/kg)10
Cmax (μmol/L)14.7
AUCtot (μmol/L-h)5.77
T1/2α (h)0.204
T1/2β (h)9.23
MRT (h)3.62
Clearance (mL/min/kg)57.8
Vss (L/kg)46.2