Table 3.

Doses delivered to mouse organs and F9 tumor (100 mg) calculated for the therapeutic isotope I-131 based on biodistributions with three I-125-labeled anti-ED-B antibody formats (mGy/MBq)

Organ, I-131
Mouse organ doses (mGy/MBq)
L19 (scFv)2L19-SIPL19-IgG1
Spleen1561163
Liver750170
Kidneys265160315
Lung79176560
Red Marrow1463186
Ovaries517586664
Uterus1339591,019
F9 Tumor (100 mg)2649251,135
MTA (MBq)947124
F9 Tumor Dose (Gy)256627
  • NOTE: The dose to a F9 tumor (100 mg) after injection of the maximum tolerated activity is additionally presented for the three I-125-labeled anti-ED-B antibody formats (Gy).