Table 1.

Relationship between human antichimeric antibody response and blood clearance of [131I]cG250

Patient no.HACA titer*
Blood clearance
PreRIT 1§Months after RIT 1
RIT 2Months after RIT 2
123123
1negn.d.n.d.n.d.63n.d.n.d.n.d.neg52.0
9negn.d.n.d.n.d.3503586,1461,03227822.0
10neg937041,324l.f.l.f.l.f.l.f.l.f.20.5
11negnegnegn.d.114n.d.178,783l.f.l.f.22.0
14negnegnegn.d.47neg24535032759.1
21negnegnegnegnegnegnegn.d.63474.0
25neg89057,893l.f.l.f.l.f.l.f.l.f.l.f.26.9
27negnegn.d.60103neg355n.d.24051.9
  • Abbreviations: HACA, human antichimeric antibody; RIT, radioimmunotherapy; neg, negative; n.d., not determined; l.f., lost to follow-up.

  • * Human antichimeric antibody titers in ng/mL NUH-91 equivalents.

  • Blood clearance as t1/2 β in hours. Blood clearance was measured at Pre, RIT 1, 3 months after RIT 1 and at RIT 2. Only one value of blood clearance per patient is shown. The depicted blood clearance corresponds to the underlined human antichimeric antibody titer.

  • Tracer 1 was given before (pre) radioimmunotherapy 1.

  • § One week after tracer 1.

  • One week after tracer 2.

  • Tracer 2 was given 3 months after radioimmunotherapy 1.